Simparica Trio All-In-One Parasite Prevention for Dogs

Simparica Trio

Overview

Simparica Trio is a monthly chewable tablet combining sarolaner, moxidectin, and pyrantel to protect dogs from fleas, ticks, heartworm, and intestinal worms. Sarolaner kills fleas and ticks rapidly, moxidectin prevents heartworm and treats certain mites, and pyrantel treats roundworms and hookworms. Approved for puppies from eight weeks of age (weighing at least 1.25 kg), Simparica Trio offers comprehensive protection in one palatable chew, reducing the need for multiple products.

Key Benefits

Rapid flea and tick kill: Sarolaner begins eliminating fleas within 3 hours and ticks within 8 hours. Heartworm prevention: Moxidectin eliminates immature Dirofilaria immitis larvae, preventing adult heartworm disease. Nematode control: Pyrantel treats roundworms (Toxocara canis) and hookworms (Ancylostoma caninum). Once-monthly convenience: One chew addresses multiple parasite threats—internal and external—in a single dose. Waterproof efficacy: Oral administration remains effective regardless of bathing or swimming.

Usage & Dosage

Administer Simparica Trio based on body weight:

• 1.25 – 2.5 kg: One 10 mg sarolaner / 0.24 mg moxidectin / 5 mg pyrantel chew monthly.
• 2.6 – 5 kg: One 20 mg sarolaner / 0.48 mg moxidectin / 10 mg pyrantel chew monthly.
• 5.1 – 10 kg: One 40 mg sarolaner / 0.96 mg moxidectin / 20 mg pyrantel chew monthly.
• 10.1 – 20 kg: One 80 mg sarolaner / 1.92 mg moxidectin / 40 mg pyrantel chew monthly.
• 20.1 – 40 kg: One 120 mg sarolaner / 2.88 mg moxidectin / 60 mg pyrantel chew monthly.
• > 40 kg: Combine chews to achieve correct dose—for example, 2× 80 mg + 1× 40 mg for a 60 kg dog.

Administer with or without food—offer directly or hide in a treat. If vomiting occurs within one hour, administer a replacement chew. Continue the 30-day schedule to maintain coverage. Store chews at room temperature in a secure, dry place away from direct sunlight.

Safety & Considerations

Simparica Trio is generally well tolerated; mild side effects—such as vomiting, diarrhoea, lethargy, or pruritus—are uncommon and transient. Use caution in dogs with a history of seizures, as sarolaner and moxidectin may lower the seizure threshold in predisposed breeds. Do not use in puppies younger than eight weeks or weighing less than 1.25 kg. Pregnant and lactating bitches can receive Simparica Trio under veterinary guidance. Avoid concurrent administration of other isoxazoline or moxidectin-containing products. Keep chews out of reach of children and other pets. In case of suspected overdose or severe reaction, contact a veterinarian immediately. Annual heartworm testing is mandatory prior to reinitiating Simparica Trio each year.

Frequently asked questions

Does Simparica Trio protect against heartworm?

Yes—moxidectin in Simparica Trio prevents heartworm by killing immature larvae.

How quickly does Simparica Trio kill ticks?

Sarolaner begins killing ticks within 8 hours of administration, reducing disease transmission risk.

Can I give Simparica Trio with food?

Yes—Simparica Trio can be administered with or without food; feeding may reduce the chance of gastrointestinal upset.

What if my dog vomits the chew?

If vomiting occurs within one hour, administer a replacement chew. If after one hour, no replacement is required; resume monthly dosing.

Is Simparica Trio safe for puppies?

Yes—approved for puppies from eight weeks of age and weighing at least 1.25 kg.